Is NMDA produced in the body?The probability of indirect human fertilization?Why are diabetic people often overweight?What is inside IDL (intermediate density lipoproteïn)?Why does vitamin D need to be exogenous?Which of the three is true for insulin receptors?How do we find antibiotics?How are the very first telomeres added?What is the connectivity between on-center & off-center bipolar cells?Effect of UV radiation on retinoid (vitamin A) receptors in the skinWhat is the difference between neurotransmitters acting as neurotransmitters and hormones?

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Is NMDA produced in the body?


The probability of indirect human fertilization?Why are diabetic people often overweight?What is inside IDL (intermediate density lipoproteïn)?Why does vitamin D need to be exogenous?Which of the three is true for insulin receptors?How do we find antibiotics?How are the very first telomeres added?What is the connectivity between on-center & off-center bipolar cells?Effect of UV radiation on retinoid (vitamin A) receptors in the skinWhat is the difference between neurotransmitters acting as neurotransmitters and hormones?













7












$begingroup$


On the wiki page for NMDA it says that NMDA is a synthetic substance that mimics glutamate. So why does the body not use glutamate instead of NMDA?



Also how is it possible that our body can produce something that is synthetic? I thought synthetic was man-made chemicals. Does that mean the NMDA receptors it binds to are also synthetic? How did this come to be?










share|improve this question











$endgroup$
















    7












    $begingroup$


    On the wiki page for NMDA it says that NMDA is a synthetic substance that mimics glutamate. So why does the body not use glutamate instead of NMDA?



    Also how is it possible that our body can produce something that is synthetic? I thought synthetic was man-made chemicals. Does that mean the NMDA receptors it binds to are also synthetic? How did this come to be?










    share|improve this question











    $endgroup$














      7












      7








      7


      1



      $begingroup$


      On the wiki page for NMDA it says that NMDA is a synthetic substance that mimics glutamate. So why does the body not use glutamate instead of NMDA?



      Also how is it possible that our body can produce something that is synthetic? I thought synthetic was man-made chemicals. Does that mean the NMDA receptors it binds to are also synthetic? How did this come to be?










      share|improve this question











      $endgroup$




      On the wiki page for NMDA it says that NMDA is a synthetic substance that mimics glutamate. So why does the body not use glutamate instead of NMDA?



      Also how is it possible that our body can produce something that is synthetic? I thought synthetic was man-made chemicals. Does that mean the NMDA receptors it binds to are also synthetic? How did this come to be?







      human-biology biochemistry molecular-biology neurophysiology neurotransmitter






      share|improve this question















      share|improve this question













      share|improve this question




      share|improve this question








      edited Apr 30 at 8:56









      WYSIWYG

      31.6k750133




      31.6k750133










      asked Apr 29 at 22:27









      user3665690user3665690

      1259




      1259




















          2 Answers
          2






          active

          oldest

          votes


















          18












          $begingroup$

          (my comment reiterating the answer seemed useful, so I've reproduced it here)



          There are "NMDA receptors" in our body. There is not NMDA naturally in our body*. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.




          (original answer)



          NMDA receptors are in fact glutamate receptors natively: there is no endogenous NMDA*. They are named NMDA receptors because experimentally they were differentiated from other glutamate receptors using the compound NMDA. At first glutamate receptors were known as "NMDA" and "non-NMDA" glutamate receptors, and later the non-NMDA sort were found to be sensitive to AMPA or kainate and named thusly.



          Many other receptors are named this way: the nicotinic acetylcholine receptor is the receptor that nicotine is an agonist at, but the endogenous ligand is acetylcholine; muscarine is an agonist to the muscarinic acetylcholine receptor but the endogenous ligand is acetylcholine.




          Watkins, J. C., & Jane, D. E. (2006). The glutamate story. British journal of pharmacology, 147(S1), S100-S108.




          *In the comments, @gilleain pointed out some research suggesting that NMDA does exist endogenously, although in fairly specific areas and not disputing that glutamate is the primary endogenous agonist for NMDA receptors. This work was long after the NMDA-sensitive glutamate receptor was discovered and named, but is some interesting trivia nonetheless.






          share|improve this answer











          $endgroup$








          • 8




            $begingroup$
            @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:02






          • 1




            $begingroup$
            I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
            $endgroup$
            – user3665690
            Apr 30 at 1:07






          • 1




            $begingroup$
            @user3665690 Yes that's correct
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:31






          • 1




            $begingroup$
            ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
            $endgroup$
            – gilleain
            Apr 30 at 15:36






          • 1




            $begingroup$
            @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
            $endgroup$
            – Bryan Krause
            Apr 30 at 15:41


















          1












          $begingroup$

          There is no clear-cut line between "synthetic" and "natural" substances. They are made from the same kinds of atoms using the same kinds of covalent, ionic, and other types of bonds. The fact that a substance MAY be produced by some organism by biological processes does not make it any different from the same substance made in a laboratory by a human chemist from non-living reactants. What is relevant is the precise structure of the substance and the impurities that may be present in a particular sample of it. Sometimes, because of the details of the kinetics and thermodynamics of biosynthetic and human laboratory synthetic processes, the relative isotopic composition of one or more of the elements may be different, but that can also be true of different "natural" processes and different "synthetic" processes.






          share|improve this answer









          $endgroup$













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            2 Answers
            2






            active

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            2 Answers
            2






            active

            oldest

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            active

            oldest

            votes






            active

            oldest

            votes









            18












            $begingroup$

            (my comment reiterating the answer seemed useful, so I've reproduced it here)



            There are "NMDA receptors" in our body. There is not NMDA naturally in our body*. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.




            (original answer)



            NMDA receptors are in fact glutamate receptors natively: there is no endogenous NMDA*. They are named NMDA receptors because experimentally they were differentiated from other glutamate receptors using the compound NMDA. At first glutamate receptors were known as "NMDA" and "non-NMDA" glutamate receptors, and later the non-NMDA sort were found to be sensitive to AMPA or kainate and named thusly.



            Many other receptors are named this way: the nicotinic acetylcholine receptor is the receptor that nicotine is an agonist at, but the endogenous ligand is acetylcholine; muscarine is an agonist to the muscarinic acetylcholine receptor but the endogenous ligand is acetylcholine.




            Watkins, J. C., & Jane, D. E. (2006). The glutamate story. British journal of pharmacology, 147(S1), S100-S108.




            *In the comments, @gilleain pointed out some research suggesting that NMDA does exist endogenously, although in fairly specific areas and not disputing that glutamate is the primary endogenous agonist for NMDA receptors. This work was long after the NMDA-sensitive glutamate receptor was discovered and named, but is some interesting trivia nonetheless.






            share|improve this answer











            $endgroup$








            • 8




              $begingroup$
              @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:02






            • 1




              $begingroup$
              I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
              $endgroup$
              – user3665690
              Apr 30 at 1:07






            • 1




              $begingroup$
              @user3665690 Yes that's correct
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:31






            • 1




              $begingroup$
              ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
              $endgroup$
              – gilleain
              Apr 30 at 15:36






            • 1




              $begingroup$
              @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
              $endgroup$
              – Bryan Krause
              Apr 30 at 15:41















            18












            $begingroup$

            (my comment reiterating the answer seemed useful, so I've reproduced it here)



            There are "NMDA receptors" in our body. There is not NMDA naturally in our body*. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.




            (original answer)



            NMDA receptors are in fact glutamate receptors natively: there is no endogenous NMDA*. They are named NMDA receptors because experimentally they were differentiated from other glutamate receptors using the compound NMDA. At first glutamate receptors were known as "NMDA" and "non-NMDA" glutamate receptors, and later the non-NMDA sort were found to be sensitive to AMPA or kainate and named thusly.



            Many other receptors are named this way: the nicotinic acetylcholine receptor is the receptor that nicotine is an agonist at, but the endogenous ligand is acetylcholine; muscarine is an agonist to the muscarinic acetylcholine receptor but the endogenous ligand is acetylcholine.




            Watkins, J. C., & Jane, D. E. (2006). The glutamate story. British journal of pharmacology, 147(S1), S100-S108.




            *In the comments, @gilleain pointed out some research suggesting that NMDA does exist endogenously, although in fairly specific areas and not disputing that glutamate is the primary endogenous agonist for NMDA receptors. This work was long after the NMDA-sensitive glutamate receptor was discovered and named, but is some interesting trivia nonetheless.






            share|improve this answer











            $endgroup$








            • 8




              $begingroup$
              @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:02






            • 1




              $begingroup$
              I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
              $endgroup$
              – user3665690
              Apr 30 at 1:07






            • 1




              $begingroup$
              @user3665690 Yes that's correct
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:31






            • 1




              $begingroup$
              ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
              $endgroup$
              – gilleain
              Apr 30 at 15:36






            • 1




              $begingroup$
              @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
              $endgroup$
              – Bryan Krause
              Apr 30 at 15:41













            18












            18








            18





            $begingroup$

            (my comment reiterating the answer seemed useful, so I've reproduced it here)



            There are "NMDA receptors" in our body. There is not NMDA naturally in our body*. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.




            (original answer)



            NMDA receptors are in fact glutamate receptors natively: there is no endogenous NMDA*. They are named NMDA receptors because experimentally they were differentiated from other glutamate receptors using the compound NMDA. At first glutamate receptors were known as "NMDA" and "non-NMDA" glutamate receptors, and later the non-NMDA sort were found to be sensitive to AMPA or kainate and named thusly.



            Many other receptors are named this way: the nicotinic acetylcholine receptor is the receptor that nicotine is an agonist at, but the endogenous ligand is acetylcholine; muscarine is an agonist to the muscarinic acetylcholine receptor but the endogenous ligand is acetylcholine.




            Watkins, J. C., & Jane, D. E. (2006). The glutamate story. British journal of pharmacology, 147(S1), S100-S108.




            *In the comments, @gilleain pointed out some research suggesting that NMDA does exist endogenously, although in fairly specific areas and not disputing that glutamate is the primary endogenous agonist for NMDA receptors. This work was long after the NMDA-sensitive glutamate receptor was discovered and named, but is some interesting trivia nonetheless.






            share|improve this answer











            $endgroup$



            (my comment reiterating the answer seemed useful, so I've reproduced it here)



            There are "NMDA receptors" in our body. There is not NMDA naturally in our body*. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.




            (original answer)



            NMDA receptors are in fact glutamate receptors natively: there is no endogenous NMDA*. They are named NMDA receptors because experimentally they were differentiated from other glutamate receptors using the compound NMDA. At first glutamate receptors were known as "NMDA" and "non-NMDA" glutamate receptors, and later the non-NMDA sort were found to be sensitive to AMPA or kainate and named thusly.



            Many other receptors are named this way: the nicotinic acetylcholine receptor is the receptor that nicotine is an agonist at, but the endogenous ligand is acetylcholine; muscarine is an agonist to the muscarinic acetylcholine receptor but the endogenous ligand is acetylcholine.




            Watkins, J. C., & Jane, D. E. (2006). The glutamate story. British journal of pharmacology, 147(S1), S100-S108.




            *In the comments, @gilleain pointed out some research suggesting that NMDA does exist endogenously, although in fairly specific areas and not disputing that glutamate is the primary endogenous agonist for NMDA receptors. This work was long after the NMDA-sensitive glutamate receptor was discovered and named, but is some interesting trivia nonetheless.







            share|improve this answer














            share|improve this answer



            share|improve this answer








            edited Apr 30 at 16:10

























            answered Apr 29 at 22:39









            Bryan KrauseBryan Krause

            20.2k33358




            20.2k33358







            • 8




              $begingroup$
              @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:02






            • 1




              $begingroup$
              I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
              $endgroup$
              – user3665690
              Apr 30 at 1:07






            • 1




              $begingroup$
              @user3665690 Yes that's correct
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:31






            • 1




              $begingroup$
              ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
              $endgroup$
              – gilleain
              Apr 30 at 15:36






            • 1




              $begingroup$
              @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
              $endgroup$
              – Bryan Krause
              Apr 30 at 15:41












            • 8




              $begingroup$
              @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:02






            • 1




              $begingroup$
              I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
              $endgroup$
              – user3665690
              Apr 30 at 1:07






            • 1




              $begingroup$
              @user3665690 Yes that's correct
              $endgroup$
              – Bryan Krause
              Apr 30 at 1:31






            • 1




              $begingroup$
              ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
              $endgroup$
              – gilleain
              Apr 30 at 15:36






            • 1




              $begingroup$
              @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
              $endgroup$
              – Bryan Krause
              Apr 30 at 15:41







            8




            8




            $begingroup$
            @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:02




            $begingroup$
            @user3665690 There are "NMDA receptors" in our body. There is not NMDA naturally in our body. "NMDA receptor" is just a name people gave to one of the receptors that normally binds glutamate. They could have called it something else, like the "slow glu receptor", or "Glutamate Receptor A", but they called it the NMDA receptor because they discovered it was different from other glutamate receptors in that it was activated by a chemical called NMDA in their experiments.
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:02




            1




            1




            $begingroup$
            I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
            $endgroup$
            – user3665690
            Apr 30 at 1:07




            $begingroup$
            I see! ok that makes a lot of sense now, so basically NMDA is a synthetic chemical that mimics glutamate induce NMDA receptor activity. Is that the right interpretation?
            $endgroup$
            – user3665690
            Apr 30 at 1:07




            1




            1




            $begingroup$
            @user3665690 Yes that's correct
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:31




            $begingroup$
            @user3665690 Yes that's correct
            $endgroup$
            – Bryan Krause
            Apr 30 at 1:31




            1




            1




            $begingroup$
            ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
            $endgroup$
            – gilleain
            Apr 30 at 15:36




            $begingroup$
            ncbi.nlm.nih.gov/pubmed/11014243 : " we show that N-methyl-D-aspartate (NMDA) is present at nanomolar levels in rat nervous system and endocrine glands as a natural compound, and it is biosynthesized in vivo and in vitro. " but anyway that's beside the point - the question includes "Also how is it possible that our body can produce something that is synthetic?"
            $endgroup$
            – gilleain
            Apr 30 at 15:36




            1




            1




            $begingroup$
            @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
            $endgroup$
            – Bryan Krause
            Apr 30 at 15:41




            $begingroup$
            @gilleain Thanks for the reference! Quite interesting, I'll have to look into related work and possibly change my worldview a bit.
            $endgroup$
            – Bryan Krause
            Apr 30 at 15:41











            1












            $begingroup$

            There is no clear-cut line between "synthetic" and "natural" substances. They are made from the same kinds of atoms using the same kinds of covalent, ionic, and other types of bonds. The fact that a substance MAY be produced by some organism by biological processes does not make it any different from the same substance made in a laboratory by a human chemist from non-living reactants. What is relevant is the precise structure of the substance and the impurities that may be present in a particular sample of it. Sometimes, because of the details of the kinetics and thermodynamics of biosynthetic and human laboratory synthetic processes, the relative isotopic composition of one or more of the elements may be different, but that can also be true of different "natural" processes and different "synthetic" processes.






            share|improve this answer









            $endgroup$

















              1












              $begingroup$

              There is no clear-cut line between "synthetic" and "natural" substances. They are made from the same kinds of atoms using the same kinds of covalent, ionic, and other types of bonds. The fact that a substance MAY be produced by some organism by biological processes does not make it any different from the same substance made in a laboratory by a human chemist from non-living reactants. What is relevant is the precise structure of the substance and the impurities that may be present in a particular sample of it. Sometimes, because of the details of the kinetics and thermodynamics of biosynthetic and human laboratory synthetic processes, the relative isotopic composition of one or more of the elements may be different, but that can also be true of different "natural" processes and different "synthetic" processes.






              share|improve this answer









              $endgroup$















                1












                1








                1





                $begingroup$

                There is no clear-cut line between "synthetic" and "natural" substances. They are made from the same kinds of atoms using the same kinds of covalent, ionic, and other types of bonds. The fact that a substance MAY be produced by some organism by biological processes does not make it any different from the same substance made in a laboratory by a human chemist from non-living reactants. What is relevant is the precise structure of the substance and the impurities that may be present in a particular sample of it. Sometimes, because of the details of the kinetics and thermodynamics of biosynthetic and human laboratory synthetic processes, the relative isotopic composition of one or more of the elements may be different, but that can also be true of different "natural" processes and different "synthetic" processes.






                share|improve this answer









                $endgroup$



                There is no clear-cut line between "synthetic" and "natural" substances. They are made from the same kinds of atoms using the same kinds of covalent, ionic, and other types of bonds. The fact that a substance MAY be produced by some organism by biological processes does not make it any different from the same substance made in a laboratory by a human chemist from non-living reactants. What is relevant is the precise structure of the substance and the impurities that may be present in a particular sample of it. Sometimes, because of the details of the kinetics and thermodynamics of biosynthetic and human laboratory synthetic processes, the relative isotopic composition of one or more of the elements may be different, but that can also be true of different "natural" processes and different "synthetic" processes.







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                answered Apr 30 at 18:02









                JDMorganArkansasJDMorganArkansas

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